Preimplantation Genetic Screening to select healthy embryos with the correct number of chromosomes does the following:
All pregnancies are at risk for a chromosome abnormality. In fact, it is estimated that half of human fertilizations carry the wrong number of chromosomes, which is a leading cause of miscarriage. The risk of having a pregnancy with a chromosome abnormality increases as females age. Unlike men, who produce millions of sperm daily, a woman is born with all of her eggs already created. The ability of her eggs to produce a healthy child decreases as she gets older. This is why a woman’s age is critical when considering the probability for getting pregnant.
In IVF cycles that do not include Preimplantation Genetic Screening, embryos are chosen primarily on their visual quality – which cannot distinguish chromosomally normal embryos from abnormal ones. IVF cycles that do include PGS enable the identification of embryos with normal chromosomes, and are more likely to result in a pregnancy that leads to a healthy baby.
Preimplantation Genetic Screening reduces time between IVF cycles by allowing the identification of a normal embryo as soon as possible. If a woman goes through an IVF cycle and a normal embryo is not identified, she can start her next cycle right away.
PGS allows for single-embryo transfer by identifying the embryo that has the best chances of implanting and leading to a healthy child. Historically, physicians would transfer multiple embryos due to low implantation rates, which commonly resulted in twin or multiple pregnancies. Multiple pregnancies can cause increased risk for complications during pregnancy, such as preterm birth, abnormal placental function, preeclampsia, and others.
Chromosome makeup is a major contributing factor to having a successful pregnancy, but there are also a number of other factors involved. You can think of chromosome material as being one piece of the puzzle, but there are other pieces that must fit together in order for a healthy pregnancy to occur. Other things that can contribute to a successful pregnancy include maternal anatomy, hormonal imbalances, inherited disorders, and blood conditions. Be sure to consult with your doctor regarding all other risk factors.
At Genesis Genetics, we use the latest technology and procedures to screen embryos for chromosomal anomalies. With this testing, we scan thousands of DNA sequences that are unique to each chromosome. This allows us to accurately identify extra or missing chromosomes. As a result, fertility doctors are able to make more informed decisions as to which embryos should be implanted, giving you the best chances for a healthy pregnancy.
Genesis Genetics was one of the first laboratories to fully validate and offer Next-Generation Sequencing (NGS) technology for clinical testing. We perform more NGS testing than any other laboratory. In partnership with Illumina, Genesis Genetics is able to take full advantage of the latest technological breakthroughs in whole genome sequencing. By using advanced platforms, like the Illumina VeriSeq™, with its exceptional data reading and scalability, we study chromosomes at a level never before possible. This provides comprehensive, accurate screening of all 46 chromosomes.