Preimplantation Genetic Screening

Preimplantation Genetic Screening (PGS) is a test that examines the chromosome material of an embryo. It can tell if the appropriate number of chromosomes are present (46), or if an abnormal number of chromosomes are present.

Benefits of Preimplantation Genetic Screening

Preimplantation Genetic Screening to select healthy embryos with the correct number of chromosomes does the following:

Increases the chance of a healthy pregnancy across all age groups

All pregnancies are at risk for a chromosome abnormality. In fact, it is estimated that half of human fertilizations carry the wrong number of chromosomes, which is a leading cause of miscarriage. The risk of having a pregnancy with a chromosome abnormality increases as females age. Unlike men, who produce millions of sperm daily, a woman is born with all of her eggs already created. The ability of her eggs to produce a healthy child decreases as she gets older. This is why a woman’s age is critical when considering the probability for getting pregnant.

maternal-age-chartReduces the likelihood of miscarriage

In IVF cycles that do not include Preimplantation Genetic Screening, embryos are chosen primarily on their visual quality – which cannot distinguish chromosomally normal embryos from abnormal ones. IVF cycles that do include PGS enable the identification of embryos with normal chromosomes, and are more likely to result in a pregnancy that leads to a healthy baby.

Reduces time between IVF cycles

Preimplantation Genetic Screening reduces time between IVF cycles by allowing the identification of a normal embryo as soon as possible. If a woman goes through an IVF cycle and a normal embryo is not identified, she can start her next cycle right away.

Allows for confident single-embryo transfer, which helps avoid the added health complications associated with twin or triplet pregnancies

PGS allows for single-embryo transfer by identifying the embryo that has the best chances of implanting and leading to a healthy child. Historically, physicians would transfer multiple embryos due to low implantation rates, which commonly resulted in twin or multiple pregnancies. Multiple pregnancies can cause increased risk for complications during pregnancy, such as preterm birth, abnormal placental function, preeclampsia, and others.

Chromosome makeup is a major contributing factor to having a successful pregnancy, but there are also a number of other factors involved. You can think of chromosome material as being one piece of the puzzle, but there are other pieces that must fit together in order for a healthy pregnancy to occur. Other things that can contribute to a successful pregnancy include maternal anatomy, hormonal imbalances, inherited disorders, and blood conditions. Be sure to consult with your doctor regarding all other risk factors.

Genesis Technology

At Genesis Genetics, we use the latest technology and procedures to screen embryos for chromosomal anomalies. With this testing, we scan thousands of DNA sequences that are unique to each chromosome. This allows us to accurately identify extra or missing chromosomes. As a result, fertility doctors are able to make more informed decisions as to which embryos should be implanted, giving you the best chances for a healthy pregnancy.

Next-Generation Sequencing in PGS

Genesis Genetics was one of the first laboratories to fully validate and offer Next-Generation Sequencing (NGS) technology for clinical testing. We perform more NGS testing than any other laboratory. In partnership with Illumina, Genesis Genetics is able to take full advantage of the latest technological breakthroughs in whole genome sequencing. By using advanced platforms, like the Illumina VeriSeq™, with its exceptional data reading and scalability, we study chromosomes at a level never before possible. This provides comprehensive, accurate screening of all 46 chromosomes.

PGS Patient Enrollment Process
A test order will be sent to Genesis Genetics by your clinic.

All patients will be enrolled and contacted within 24 hours by a Genesis Genetics case coordinator via email.

Once consent forms and payment information have been received, samples can be sent from the clinic for testing.

Our team will begin testing once the samples arrive at our laboratory. Results will be available within 7 days.

Results are directly released to the clinic and ordering physician.

What People Are Saying

  • Our centers in California and in Utah have been clients of Genesis since those early FISH beginnings.  While the number of laboratories offering PGS/PGD has since exploded, Genesis has, through unabated integrity, remained our PGS/PGD gold standard.  In response to our endless unreasonable questions at unreasonable hours, Genesis staff have remained perennially patient, professional and always enlightening.

    Bronte A. Stone, MAgSc, PhD (Med), HCLD (ABB)Director of Laboratories, California Fertility Partners
  • Our clinic has partnered with Genesis Genetics for over 5 years and in that time we have discovered a dedicated team of professionals willing to go the extra mile for us AND our patients.  Their customer service and compassion-focused approach to providing a valuable service is second-to-none. We are honored to partner with such a wonderful company!

    Susan Walker, ELS (AAB), MT (AAB)Embryologist, Fertility Center, LLC
  • My twin girls (Ellie and Kaya Schneider) are 7 years old this last Feb. Time flies. I'm still determined at some point in time to come to Detroit and meet you in person so I can shake your hand. I read a recent article from someone talking about how "test tube babies" don't turn out the same as regular babies mentally, etc. I wished I could have sent the author both my daughters school updates and let this lady know that both my girls are in the accelerated math and reading classes...probably doing better than the author's kids. Anyways, hope you are doing well and continuing to help so many families like you did for us 8 years ago!

    Mike & DannitPGS Patients
  • Abington IVF & Genetics has been using Genesis Genetics for our PGD/PGS cases for over 16 years. Customer service has been top quality. If we have questions regarding anything from procedures to shipping they answer our questions promptly and are always very friendly and willing to help. Patients are anxious to receive their results and Genesis Genetics has the results ready in a timely fashion. Our patients have been happy with their counseling services and our practice appreciates their professionalism.

    Scott E. Smith, PhD, HCLDAbington IVF & Genetics
  • I wanted to share the wonderful news with you and your team that my husband Brett and I welcomed our baby girl, Charlotte Poppy, on February 11, 2016! We waited to find out the gender and were so very happily surprised to find out we had a little girl! She was 6.1 lbs. and 18.5 inches long when she was born, and was already 8.3 lbs. and 21 inches long at her 1-month appointment! We are so in love with her and are so grateful for what you all do to make this little miracle possible.

    MeganPGS Patient
  • We just wanted to thank everyone that worked on our case, and to let them know that on this past Saturday, April 30, 2011, thanks to Genesis Genetics and RMA of New Jersey, we had a beautiful daughter named Khloe. She is 8 lbs., 3 oz., and healthy. Photos to follow soon. Please thank everyone that worked on our case—words cannot express how grateful Hanna and I feel. Thank you for everything that you all do day after day.

    Kevin & HannaPGS Patients
  • While doing routine blood work for IVF, my husband and I were shocked to learn that we are both carriers for cystic fibrosis. We were so grateful to learn about Genesis Genetics and used Preimplantation Genetic Diagnosis. Words cannot express how joyful my husband and I are to have conceived two healthy girls, free from the dangers of this serious disease. Dr. Hughes and his staff were available to answer all of our questions and helped us when we were anxious during the process. We are so in love with our girls. Their health is a gift that we received from the team at Genesis Genetics.

    LauraPGD Patient

Any Questions?

To speak with a Genesis representative, please reach out via phone or email.

Contact Us

Genesis Genetics welcomes the opportunity to discuss our services—and your specific situation—in more detail. Send us an email and we'll get back to you ASAP.

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